Brady will outduel Manning on Sunday night

Normal 0 false false false EN-US X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin-top:0in; mso-para-margin-right:0in; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0in; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin;} It's a massive week in the NFL, with several playoff contenders going head-to-head.  The Patriots-Colts game headlines NFL Week 10 picks, so let's take a quick look at all the big games.

Patriots at Colts

Sunday, Nov. 15 at 8:20 p.m. ET

The hometown Colts are favored by three in this matchup. Peyton Manning and Tom Brady are the main topic of discussion, and fairly so. Their grip on the title of "NFL's top two quarterbacks" isn't loosening, even with Drew Brees playing so well in New Orleans. Brady and Manning share nearly identical stats, with 16 touchdowns and five interceptions a piece.

On Sunday night, though, Brady gets a big edge. Indy defensive backs Kelvin Hayden and Marlin Jackson won't be suiting up, meaning two rookies will start at corner. Randy Moss should have a field day. Bet on the Patriots to win.

AFC Northbet: Bengals at Steelers

Sunday, Nov. 15 at 1:00 p.m. ET

This should be a brutal, hard-hitting contest. Both teams are tied at 6-2 (Pittsburgh is favored by seven), but Cincy has the lead in the AFC North thanks to a Week 3 win over Pittsburgh. The Bengals came through in the dying seconds of the game but may have sparked Pittsburgh's five-game winning streak.

The Steelers and Bengals can both play defense, and both are brilliant at stopping the run. That gives Pittsburgh a big advantage. If the Steelers ground game is stuffed, they can turn to Ben Roethlisberger to carry the offense; the Bengals, however, don't have the same confidence in Carson Palmer, who's been average at best this season. Look for the Steelers to shut down the run and Big Ben to spearhead a win.

Eagles at Chargers

Sunday, Nov. 15 at 4:15 p.m. ET

Sportsbook odds like the Chargers by two. This is a tough matchup to handicap since neither team has been particularly consistent over the past few years. Philly dropped a heartbreaker to the Cowboys last week after allowing a long touchdown pass in the fourth quarter. The defense shouldn't be blamed, though, and played fairly well save for that one play. The offense was ineffective—Donovan McNabb must get on track.

The Chargers won their third straight with a last-second comeback over the Giants. Philip Rivers looked calm and collected during the game-winning touchdown drive. His favorite target, Vincent Jackson, has quietly turned into one of the NFL's top receivers. Defensively, the Chargers might be turning a corner. Shawne Merriman, held sackless in his first five outings, has four QB drops in his past two starts.

This is the perfect letdown game we've grown accustomed to San Diego over the past few seasons. Yes, the Chargers won three straight, but two wins came over Oakland and Kansas City. Look for the defense to sag once again while McNabb hooks up with his explosive receivers a few times. Bet on Philly.